Effect of silence information regulator 3 on temporomandibular joint osteoarthritis
10.3760/cma.j.cn112144-20220203-00043
- VernacularTitle:沉默信息调节因子3对颞下颌关节骨关节炎的影响
- Author:
Yuzhi YANG
1
;
Yanfang YU
;
Mengjie WU
Author Information
1. 浙江大学医学院附属口腔医院正畸科·浙江大学口腔医学院 浙江省口腔疾病临床医学研究中心 浙江省口腔生物医学研究重点实验室 浙江大学癌症研究院，杭州310006
- Keywords:
Temporomandibular joint;
Temporomandibular disorders;
Epigenetics;
Acetylation modification;
SIRT3
- From:
Chinese Journal of Stomatology
2022;57(7):756-761
- CountryChina
- Language:Chinese
-
Abstract:
Temporomandibular joint osteoarthritis (TMJOA) is a common subclass of temporomandibular disorders, with complicated causes and limited treatment. In addition to inflammatory reaction, structural changes of temporomandibular joint (TMJ) as condylar osteophyte formation, sclerosis, erosion, and subchondral bone cysts will happen at the same time. At present, it is found that epigenetic regulation can affect the growth and development of TMJ and regulate the immune inflammatory reaction, so we can speculate that epigenetic modification is involved in the occurrence and development of TMJOA. This paper reviews the researches of silence information regulator 3 (SIRT3), which is a key factor in epigenetics, in the field of osteoarthritis and rheumatoid arthritis.In order to discuss the effect of SIRT3 on the growth and development of TMJ by mediating acetylation modification, such as bone, cartilage, synovium and blood vessels, as well as alleviating osteoarthritis and synovitis. By doing this, the understanding of TMJOA can be enriched, with the goal of finding a new possibility for the clinical treatment of TMJOA.
