Epigenetic regulation in tooth development
10.3760/cma.j.cn112144-20200518-00283
- VernacularTitle:表观遗传在牙发育中的作用
- Author:
Ruoqing ZHONG
1
;
Hua TIAN
;
Xuejun GAO
Author Information
1. 北京大学口腔医学院·口腔医院牙体牙髓科 国家口腔疾病临床医学研究中心 口腔数字化医疗技术和材料国家工程实验室 口腔数字医学北京市重点实验室 100081
- Keywords:
DNA methylation;
Tooth development;
Protein modification, translational;
Non-coding RNA regulation
- From:
Chinese Journal of Stomatology
2021;56(3):288-293
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetics refers to genetic regulation patterns that gene expressions, which lead to the phenotype variance, are modified in the absence of changes of DNA sequence. Epigenetics mainly includes DNA methylation, histone modification, and non-coding RNA regulation. During the development of the teeth, conventional gene regulation and epigenetics synergistically regulate the spatial and temporal expression of genes, which involved in cell proliferation, differentiation and finally the formation of teeth. Exploration of the epigenetic regulation mechanisms during tooth development can provide multiple clues and ideas for the research of tooth regeneration. This article reviewed the significant roles of epigenetic regulation in tooth development.
