A clinical trial on the desensitizing effect of a toothpaste containing 8％ arginine
10.3760/cma.j.issn.1002-0098.2011.s1.026
- VernacularTitle:8％精氨酸牙膏降低牙本质敏感的临床试验
- Author:
Xi LIU
1
;
Wen-Sheng RONG
;
Wei-Jian WANG
;
Tao XU
Author Information
1. 北京大学口腔医学院(口腔医院)
- Keywords:
Dentine sensitivity;
Arginine;
Desensitizing toothpaste;
Visual analogue scale
- From:
Chinese Journal of Stomatology
2011;46(z1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the desensitizing effect of a new toothpaste containing 8％ arginine,calcium carbonate,and 1450 mg/kg fluoride as sodium monofluorophosphate(MFP).Methods This was a 1-week randomized,double-blinded,controlled,parallel-design clinical trial.A total of 88 subjects were recruited into the study and stratified into 2 balanced groups according to their baseline air blast sensitivity scores in visual analogue scale(VAS).The two groups were randomly assigned to use either the new arginine toothpaste or the commercially available desensitizing toothpaste containing 5.53％ potassium citrate.After baseline examination,a single topical application of the assigned toothpaste was directly onto the hypersensitive surface of each of the two baseline-designated hypersensitive teeth and massaged each surface for one minute.Then,the subjects were asked to brush their teeth twice-daily athome with the assigned toothpaste and a commercially available soft-bristled toothbrush for one week.Dentin hypersensitivity assessments,in air blast and self-perceived,were conducted at baseline,immediately after direct topical application,and after three days and one week of toothpaste use.Results A total of 88 subjects (44 in test and 44 in control groups) completed the study.At baseline,there was no statistically significant differences in mean air blast sensitivity VAS score ( 55.51 ± 8.48 in test group and 56.67 ±10.22 in control group ) and self-perceived sensitivity VAS score between the two groups(43.75 ± 6.65 in test group and 41.98 ± 8.53 in control group) (P ＞ 0.05 ).Compared to the control group,the test group exhibited statistically significant reductions (P ＜ 0.05 ) in air blast sensitivity VAS score ( 12.61 ± 12.86) and self-perceived sensitivity VAS score( 12.95 ± 8.29) immediately after directly application.Relative to the control toothpaste groups,the 8％ arginine group exhibited statistically significant( P ＜ 0.05 ) reductions in sensitivity after the subsequent three days ( 15.16 ± 13.21 in air blast sensitivity VAS score and 13.33 ±8.38 in self-perceived sensitivity VAS score) and one week( 15.80 ± 16.48 in air blast sensitivity VAS score and 14.49 ± 11.04 in self-perceived sensitivity VAS score ) of twice-daily regular tooth brushing.Conclusions A single topical application of a new 8％ arginine toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvement in dentin hypersensitivity.The improvement demonstrated by the 8％ arginine toothpaste after directly application was maintained after three days and one week of twice-daily brushing.
