Relationship between matrix metalloproteinases-8 and metalloproteinases inhibitors levels in gingival crevicular fluid in periodontal disease
10.3760/cma.j.issn.1002-0098.2011.s1.007
- VernacularTitle:龈沟液中基质金属蛋白酶8及基质金属蛋白酶组织抑制物1水平与牙周病的关系
- Author:
Ping CHEN
1
;
Yi XUE
;
Dong-Hui YUAN
Author Information
1. 白求恩国际和平医院
- Keywords:
Periodontitis;
Matrix metalloproteinase 8;
Periodontics;
Matrix metalloproteinase inhibitors
- From:
Chinese Journal of Stomatology
2011;46(z1):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the levels of matrix metalloproteinases(MMP)-8 and tissus inhibitors of metalloproteinases (TIMP)-1 in gingival crevicular fluid (GCF)and periodontal disease.Methods Fourteen patients with chronic periodontitis,18 cases with marginal gingivitis and 16 subjects with normal gingiva were selected in this study.The level of MMP-8 and TIMP-1 was detected by enzyme-linked immunosorbent assay (ELISA) and compared among the three groups.Results The average concentrations of MMP-8 of control group,chronic marginal gingivitis group and chronic periodontitis group were (0.62 ± 0.09),(0.68 ± 0.02) and (0.78 ± 0.05 ) mg/L,respectively.The difference was significant among the three groups (P ＜ 0.05 ).The average concentrations of TIMP-1 of the three groups were (3.55 ±0.93),(3.42 ± 1.49) and (2.88 ± 1.30) mg/L,respectively.There was no significant difference among the three groups ( P ＞ 0.05 ).The MMP-8/TIMP-1 ratios of the three groups were 0.16 ±0.06,0.23 ±0.09 and 0.32 ±0.15,respectively.The difference was significant (P ＜0.05).Conclusions The MMP-8 level and MMP-8/TIMP-1 ratio can be considered as two valuable clinical indicators for periodontal tissue destruction and inflammation degree.
