Predictive values of combined detection of Lp-PLA2,PAR-2 and AOPP for in-stent restenosis after PCI
10.13699/j.cnki.1001-6821.2024.18.018
- VernacularTitle:Lp-PLA2、PAR-2、AOPP联合检测对PCI术后支架内再狭窄的预测价值
- Author:
Xiao-Dong HOU
1
;
Peng ZHANG
;
Xin-Kuan WANG
;
Fan DING
;
Kang YI
;
Tao YOU
Author Information
1. 甘肃省人民医院心血管外科,甘肃兰州 730000
- Keywords:
lipoprotein-associated phospholipase A2;
percutaneous coronary intervention;
in-stent restenosis;
percutaneous coronary intervention;
advanced oxidation protein products
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(18):2695-2698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the combined detection of lipoprotein-associated phospholipase A2(Lp-PLA2),protease activated receptor 2(PAR-2),and advanced oxidation protein products(AOPP)and the occurrence of in-stent restenosis after percutaneous coronary intervention(PCI),as well as its predictive value.Methods Patients with coronary heart disease after PCI were selected as the study objects.Group Ⅰ was the group without in-stent restenosis and group Ⅱ was the group with in-stent restenosis.The expressions of Lp-PLA2,PAR-2 and AOPP were detected by enzyme-linked immunosorbent assay(ELISA),and the predictive value and independent risk factors of these gene expression changes and the risk of in-stent restenosis were analyzed by receiver operating characteristic(ROC)analysis and binary logistic regression analysis.Results The blood Lp-PLA2 levels in group Ⅰ and group Ⅱ after 1 year follow-up after stenting were(190.24±33.67)and(256.14±37.68)ng·mL-1;PAR-2 levels were(1.41±0.38)and(1.95±0.43)ng·L-1,respectively;the AOPP levels were(47.25±4.62)and(58.76±4.86)μmol·L-1,respectively,and the differences were statistically significant(all P＜0.001).ROC analysis results showed that the truncation values of Lp-PLA2,PAR-2 and AOPP were 201.32 ng·mL-1,1.50 ng·mL-1 and 49.37 μmol·L-1,respectively.The area under the curve(AUC)was significantly higher than that detected alone(all P＜0.001).Binary logistic regression analysis shows that the independent risk factors for in-stent restenstenosis after PCI were Lp-PLA2 ≥ 201.32 ng·mL-1,PAR-2≥1.50 ng·L-1,AOPP ≥49.37 μmol·L-1 and LDL-C≥3.03 mmol·L-1,respectively(all P＜0.05).Conclusion The occurrence of in-stent restenosis after PCI is closely related to the increase in Lp-PLA2,PAR-2 and AOPP expression.
