Clinical trial of different target concentrations of propofol in elderly patients undergoing painless fiberoptic bronchoscopy
10.13699/j.cnki.1001-6821.2024.18.005
- VernacularTitle:不同靶浓度丙泊酚用于老年无痛纤维支气管镜检查患者的临床研究
- Author:
Yan-Zhi XUE
1
;
Juan-Juan FANG
;
Lin XIAO
;
Shu-Qing ZHANG
Author Information
1. 山东大学齐鲁医院德州医院日间手术科,山东德州 253000
- Keywords:
Propofol emulsion injection;
Remifentanil hydrochloride for injection;
target-controlled infusion;
elderly;
fiberoptic bronchoscopy;
anesthesia quality;
intubation time
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(18):2630-2634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influence of target-controlled infusion with different target concentrations of propofol and remifentanil on elderly patients undergoing painless fiberoptic bronchoscopy.Methods Elderly patients undergoing painless fiberoptic bronchoscopy were divided into low-dose group,middle-dose group and high-dose group.Target-controlled infusion with remifentanil and propofol was performed in low-dose group,middle-dose group and high-dose group,and the target effect-site concentrations of remifentanil all were 3.0 ng·mL-1,and the target effect-site concentrations of propofol were 3.0,4.0 and 5.0 μg·mL-1,respectively.The examination began when the target effect-site concentrations of propofol and remifentanil both reached the target concentrations.The anesthesia effect,anesthesia quality(anesthesia time,patient comfort and operator anesthesia satisfaction),recovery time,intubation time and the safety was evaluated.Results The low-dose,middle-dose and high-dose groups included 31,36 and 35 patients,respectively.The excellent and good rate of anesthesia in low-dose group,middle-dose group and high-dose group were 67.74％(21 cases/31 cases),77.78％(28 cases/36 cases)and 82.86％(29 cases/35 cases),respectively.The difference between middle-dose group and high-dose group and low-dose group was statistically significant(all P＜0.05).In the low-dose group,the middle-dose group and the high-dose group,the satisfaction of anesthesia were(6.13±1.19),(7.48±1.25)and(6.50±1.07)min,respectively;the recovery time were(7.01±1.64),(7.58±1.30)and(9.42±1.58)min,respectively;the intubation time were(9.94±2.02),(10.76±1.97)and(13.18±2.25)min,respectively.There were statistically significant differences between low-dose group and middle-dose group and high-dose group(all P＜0.05).The duration of anesthesia in low-dose group,middle-dose group and high-dose group were(31.18±4.26),(29.96±5.08)and(28.74±5.43)min,respectively;the comfort level were(8.95±0.49),(9.03±0.41)and(9.12±0.38)min,respectively;the incidence of hypotension was 12.90％,5.56％and 14.29％;the incidence of physical activity was 16.13％,8.33％and 5.71％;the incidence of cough was 19.35％,13.89％and 11.43％,respectively,The satisfaction of anesthesiologists in the meddle-dose group was significantly higher than that in the low-dose group and the high-dose group,and the differences were statistically significant(all P＜0.05).Conclusion Target-controlled infusion with propofol at a target effect-site concentration of 4.0 μg·mL-1 and remifentanil at a target effect-site concentration of 3.0 ng·mL-1 has the optimal anesthesia quality,the shortest recovery time and intubation time and good safety in elderly patients with painless fiberoptic bronchoscopy.
