Research progress of Chinese medicine regulating AGE-RAGE signaling pathway in the treatment of polycystic ovary syndrome
10.13699/j.cnki.1001-6821.2024.17.029
- VernacularTitle:中药调控AGE-RAGE信号通路治疗多囊卵巢综合征的研究现状
- Author:
Bing-Qing RAN
1
;
Jin-Ge HUANG
;
Yue-Juan WU
;
Fang WANG
Author Information
1. 甘肃中医药大学中西医结合临床医学院,甘肃兰州 730000
- Keywords:
traditional Chinese medicine;
polycystic ovary syndrome;
advanced glycation end products-receptor for advanced glycation end products signaling pathway;
treatment
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(17):2596-2600
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disease in gynecology.The main clinical manifestations are infertility,hirsuty,obesity,menstrual disorders,etc.,which seriously affect women's health.Studies have shown that the mechanism of action of traditional Chinese medicine in the treatment of PCOS involves a variety of signaling pathways,among which advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway is an important pathway regulating inflammation and oxidative stress.More and more Chinese herbal compounds,single herbs and their extracts can reduce inflammation,oxidative stress,insulin resistance and hyperandrogenemia in patients by regulating AGE-RAGE signaling pathway,which provides a new strategy and direction for the treatment of PCOS.However,there is currently no comprehensive summary of Chinese medicine intervention in the treatment of PCOS by AGE-RAGE signaling pathway.Therefore,this paper reviews the current research status of Chinese medicine regulation of AGE-RAGE signaling pathway in the treatment of PCOS in recent years,so as to provide new directions and thoughts for further research on PCOS.
