Study on influencing factors of venous thromboembolism in pneumonia patients
10.13699/j.cnki.1001-6821.2024.17.005
- VernacularTitle:肺炎患者伴发静脉血栓栓塞症的影响因素研究
- Author:
Rui-Juan LI
1
;
Jing NIU
;
Peng-Yan JIA
;
Zhuo ZHANG
;
Cheng-Li QUE
;
Qian XIANG
;
Yi-Min CUI
Author Information
1. 北京大学第一医院,临床药理研究所,北京 100034;山西白求恩医院(山西医学科学院)、山西医科大学第三医院、同济山西医院药学部,山西太原 030032;山西医科大学药学院,山西太原 030001
- Keywords:
pulmonary;
venous thromboembolism;
incidence;
nomogram
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(17):2479-2482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the incidence of venous thromboembolism(VTE)in pulmonary patients and explore the assessment and prevention of the risk of pneumonia accompanied VTE.Methods The patients with pneumonia were divided into control group(simple pneumonia)and treatment group(with VTE)according to the condition of VTE.Demographic data,blood routine,coagulation index,liver and kidney function index and blood gas index were collected.Statistical methods like chi square test,t-test and nonparametric rank sum test were applied to compare the differences between the two groups.Finally,the nomogram was established according to the logistic regression results and the receiver operating characteristic(ROC)curve was calculated.Results 106 cases in control group and 29 cases in treatment group.Univariate analysis showed that age,D-dimer,fibrinogen degradation products,white blood cell count,neutrophil count,albumin-globulin ratio were statistically significant(P＜0.05).Multivariate logistic regression analysis suggests that age[odds ratio(OR)=1.052],D-dimer(OR=2.339),and albumin/globulin(OR=0.042)are independent affecting factors for VTE in pneumonia patients.A nomogram was developed and ROC was calculated,the area under curve(AUC)was 0.754.Conclusion High age,elevated D-dimer and decreased albumin/globulin are independent risk factors for VTE in pneumonia patients.More over,the established prediction model has good accuracy.
