Role of Hedgehog signaling pathway in muscle bone symbiosis in osteo-sarcopenia

VernacularTitle:Hedgehog信号通路在肌少-骨质疏松症中的肌骨共生作用
Author: Yan-Dong LIU ¹ ; Qiang DENG ; Zhong-Feng LI ; Ran-Dong PENG ; Yu-Rong WANG ; Jia-Ming LI ; Ping-Yi MA ; Jian-Qiang DU
Author Information

1. 甘肃中医药大学研究生院,甘肃兰州 730000
Keywords: Hedgehog signaling pathway; muscle deficiency osteoporosis; myoblast; osteogenesis; mechanism of action
From: The Chinese Journal of Clinical Pharmacology 2024;40(16):2433-2437
CountryChina
Language:Chinese
Abstract: This article elaborates on the complex cross-talk and close relationship between muscles and bones involved in this disease,as well as its pathogenesis.It also summarizes that the difficulty of its treatment lies in the need to simultaneously consider both muscles and bones.And elaborated on the key role of the Hedgehog signaling pathway in embryonic development,tissue morphology establishment,and human tissue regeneration and repair.Investigated the remodeling effect of the Hedgehog signaling pathway on skeletal muscle from three aspects:Proliferation and differentiation of muscle stem cells,precursor cell and muscle fiber generation,inhibition of inflammation,and regulation of immunity;this article elucidates the role of the Hedgehog signaling pathway in bone reconstruction from two aspects.