Research status on the role of NLRP3 inflammasome in tumor micro-environment on breast cancer metastasis
10.13699/j.cnki.1001-6821.2024.14.030
- VernacularTitle:肿瘤微环境中NLRP3炎症小体对乳腺癌转移的研究现状
- Author:
Lin-Ye HUA
1
;
Hong-Shan LUO
;
Xiu-Lian LIN
;
Li-Mei LIN
;
Bo-Hou XIA
;
Ya-Mei LI
Author Information
1. 湖南中医药大学药学院湘产大宗药材品质评价湖南省重点实验室,湖南长沙 410208;湖南中医药大学医学院,湖南长沙 410208
- Keywords:
breast cancer;
tumor metastasis;
NOD-like receptor thermal protein domain associated protein 3 inflammasome;
tumor micro-environment
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(14):2148-2152
- CountryChina
- Language:Chinese
-
Abstract:
The expression level of NOD-like receptors(NLRP3)inflammasome is significantly elevated in breast cancer tissues,and a high level of NLRP3 inflammasomes is closely associated with breast cancer metastasis.Activation of NLRP3 inflammasome can induce the release of inflammatory factors into the tumor microenvironment(TME).These inflammatory factors,by signaling to cancer cells,reshape the TME to promote tumor growth and invasion,ultimately facilitating the process of epithelial-mesenchymal transition.This equips cancer cells with the ability to establish distant metastases and increase the formation of metastatic lesions.This review addresses the current research status and prospects of NLRP3 inflammasomes in the breast cancer TME and their role in breast cancer metastasis.The goal is to provide new insights for the study of breast cancer metastasis mechanisms and treatment strategies.
