Research status on the mechanism of sinomenine in treatment of Alzheimer's disease
10.13699/j.cnki.1001-6821.2024.14.028
- VernacularTitle:青藤碱治疗阿尔茨海默病机制的研究现状
- Author:
Zheng-An MA
1
;
Xi-Xiang LI
Author Information
1. 甘肃省中医院药学部,甘肃兰州 730050
- Keywords:
sinomenine;
Alzheimer's disease;
microglia;
astrocytes;
oxidative stress;
inflammation
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(14):2139-2142
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is one kind of disruptive neurodegenerative disease which can lead to severe cognitive dysfunction.Sinomenine can inhibit the activation of astrocytes,increase of oxidative stress and levels of inflammatory factors,protect neurons from indirect toxicity of astrocytes,inhibit microglial-mediated neuroinflammation,inhibit acetyl cholinesterase and β-site amyloid precursor protein cleaving enzyme-1 activities in AD,thus exert anti AD effects.According to review the molecular mechanisms of sinomenine in treatment of AD,we aim to provide a basis for the development of new drugs for treatment of AD.
