Research on population pharmacokinetics of propofol injection in adult patients under general anesthesia
10.13699/j.cnki.1001-6821.2024.14.025
- VernacularTitle:丙泊酚注射液在成年全麻患者中的群体药代动力学研究
- Author:
Jin-Xia LI
1
;
An-Cheng GU
;
Fu-Miao YUAN
;
Cai LI
;
Hai-Jun DENG
;
Zhong-Yuan XU
Author Information
1. 南方医科大学南方医院临床药学中心,广东广州 510515;南方医科大学国家药品监督管理局药物代谢研究与评价重点实验室及广东省新药筛选重点实验室,广东广州 510515
- Keywords:
propofol;
population pharmacokinetics;
individual administration;
gene polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(14):2124-2128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitatively assess the influence of various factors on the pharmacokinetic parameters of propofol and to develop a propofol population pharmacokinetic model tailored for Chinese patients.Methods Thirty patients scheduled for selective abdominal surgeries received an anesthesia dose of propofol at 2.0 mg·kg-1.The concentration of propofol in collected venous blood samples was measured using liquid chromatography-tandem mass spectrometry.Polymorphisms in metabolizing enzyme genes were detected through Sanger sequencing technology.Pharmacokinetic parameters were computed,and models were constructed and evaluated using Phoenix Winnonlin software.Results Through software analysis,the drug's in vivo process was best described by a three-compartment model.The population mean values for the central compartment clearance rate(CL),shallow peripheral compartment clearance rate(Q2),deep peripheral compartment clearance rate(Q3),central compartment volume of distribution(V),shallow peripheral compartment volume of distribution(V2),and deep peripheral compartment volume of distribution(V3)were 1.71 L·min-1,1.31 L·min-1,1.51 L·min-1,5.92 L,19.86 L and 99.06 L,respectively.Body weight was identified as a significant covariate affecting CL and V,and was incorporated into the model.Conclusion The evaluation of the final model demonstrates its substantial predictive capability,offering directional guidance for the clinical administration of propofol.
