Mechanism and research progress of S100A8/A9 in the microenvironment before high-risk tumor metastasis

VernacularTitle:S100A8/A9在高发肿瘤转移前微环境中的作用机制及研究现状
Author: Hai-Xia MING ¹ ; Zhao-Hua LIU ; Yan-Jun WANG ; Ming SHEN ; Yan-Wen CHEN ; Yang LI ; Ling-Ling YANG ; Qian-Kun LIANG
Author Information

1. 甘肃中医药大学基础医学院,甘肃兰州 730000;甘肃中医药大学中西医结合基础学科,甘肃兰州 730000;甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州 730000;甘肃省中医药防治慢性疾病重点实验室,甘肃兰州 730000
Keywords: tumor; inflammation; immunity; S100 calc-binding protein A8/A9
From: The Chinese Journal of Clinical Pharmacology 2024;40(13):1991-1995
CountryChina
Language:Chinese
Abstract: S100 calc-binding protein A8/A9(S100A8/A9)can induce the migration of primary tumor cells to distant target organs by binding multiple channel proteins,promote the formation of tumor metastasis microenvironment,and play an important role in the immune and inflammatory response of the body.It provides a new target and idea for the prevention and treatment of tumor metastasis and invasion.This paper mainly reviewed the expression and mechanism of S100A8/A9 on related channel proteins in a variety of high incidence tumors,in order to provide a new strategy for tumor prevention,diagnosis and treatment.