Research status of Wnt5a-Frizzled-2 pathway and ischemia-reperfusion injury
10.13699/j.cnki.1001-6821.2024.13.026
- VernacularTitle:Wnt5a-Frizzled-2通路与缺血再灌注损伤的研究现状
- Author:
Zhi-Peng SUN
1
;
Shu-Su DONG
;
Chuan-Cheng MA
;
Chen-Ying WANG
;
Fei CHEN
;
Hai-Ying WANG
Author Information
1. 济宁医学院临床医学院,山东济宁 272067
- Keywords:
Wnt5 a-Frizzled-2;
cell apoptosis;
autophagy;
ischemia-reperfusion injury
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(13):1972-1976
- CountryChina
- Language:Chinese
-
Abstract:
The Wnt signaling pathway includes both classical and non classical pathways,Wnt5a-Frizzled-2 pathway participates in the Wnt/Ca2+signaling pathway in the non-classical pathway,which is activated by the Wnt-related protein Wnt5a and its ligand Frizzled-2.It can regulate some key sites in cells to affect cell signal transduction,and is closely related to cell growth process.Activation of Wnt5a-Fizzled-2 pathway occurs in some tissues with abundant blood supply,such as heart and brain tissues,during ischemia-reperfusion.Activation of the Wnt5a-Frizzled-2 pathway causes these intracellular calcium overload,ultimately promoting apoptosis.This article reviews the abnormal activation of Wnt5a-Frizzled-2 signaling pathway in ischemia-reperfusion injury diseases and the induced calcium overload leading to apoptosis,in order to provide reference for the study of physiological mechanisms of ischemia-reperfusion injury.
