Research status of H2S-miRNA crosstalk in neurological diseases
10.13699/j.cnki.1001-6821.2024.11.031
- VernacularTitle:H2 S-miRNA串扰在神经系统疾病中的研究现状
- Author:
Shuo CAO
1
;
Yun-Jia SONG
;
Qing ZHONG
;
Rong ZHANG
;
Xu-Tao SUN
Author Information
1. 黑龙江中医药大学基础医学院,黑龙江哈尔滨 150000
- Keywords:
hydrogen sulfide;
microRNA;
neurological diseases cerebrovascular disease;
spinal cord diseases;
neurodegenerative disease
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(11):1684-1688
- CountryChina
- Language:Chinese
-
Abstract:
Hydrogen sulfide(H2S)is an emerging endogenous neuromodulator that holds significant potential in the realm of neurological diseases.Its role encompasses reducing neuronal damage,inhibiting excessive activation of striatal astrocytes,and regulating cerebrovascular function,among other physiopathological pathways.Conversely,microRNAs(miRNAs)are widely recognized as pivotal regulators of neurological diseases.They primarily target the 3'untranslated region of the target gene mRNA,impeding mRNA translation and hindering its expression to impart neuroprotective effects.Recent findings have underscored the crucial involvement of H2S and miRNAs in the pathogenesis of various neurological disorders such as Parkinson's disease,stroke,and spinal cord diseases,thereby garnering significant attention.This paper comprehensively summarizes the protective effects arising from the interplay between H2S and miRNAs in neurological diseases,while also delving into the potential therapeutic efficacy they hold for such conditions.
