A study of drugs related to contraindications in children in the 2020 edition of the Chinese Pharmacopoeia
10.13699/j.cnki.1001-6821.2024.09.024
- VernacularTitle:2020年版《中国药典》儿童禁忌相关药品研究
- Author:
Yu YANG
1
;
Rui-Ling ZHAO
;
Xin-Wen XU
;
Zhi-Gang ZHAO
Author Information
1. 山西省儿童医院临床试验机构办公室,山西太原 030013
- Keywords:
children;
contraindicated;
pharmaceuticals;
drug label;
medication safety
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(9):1355-1359
- CountryChina
- Language:Chinese
-
Abstract:
Objective The varieties of chemical drugs prohibited for children in the 2020 edition of Chinese Pharmacopoeia were analyzed.Provide a technical basis for the development of a list of drugs prohibited by children.This is requirement of China's Children's Development Program(2021-2030).Methods Drug inserts are collected through websites such as"PharmaIntelligence",from which information on children's prohibitions is extracted,and drugs with consistent information on children's prohibitions are analyzed in the instructions of different manufacturers.Results Among the 1 741 kinds of chemicals,there are a total of 240 drugs with consistent information on the prohibition of children in the instructions of different manufacturers,of which 113 are labeled"prohibited"for children of different ages,53 are"not suitable"for children of different ages,38 are"not recommended""for children of different ages,and 36 are labeled with other children's prohibition related information.According to the classification of the clinical drug instructions involving 21 categories.Including anti-infective drugs(77),nonsteroidal anti-inflammatory drugs and anti-gout drugs(28),nervous system drugs(20),psychotropic drugs(16),digestive system drugs(16),endocrine system drugs(16),etc.Conclusion Children are at a special stage of growth and development,and the pharmacological and toxicological characteristics of drugs in children are different from those in adults.The risk-benefit ratio of drugs used in children needs continuous research to provide more detailed evidence for drug use and ensure the safety of drug use in children.
