Regulation of microRNA in the development of primary hepatocellular carcinoma
10.13699/j.cnki.1001-6821.2024.08.030
- VernacularTitle:MicroRNA在原发性肝细胞癌发展中的调节作用
- Author:
Da-Wei CHEN
1
;
Zhi-Xin WANG
;
Heng LI
;
San-Qiang LI
Author Information
1. 河南科技大学基础医学与法医学院肝脏损伤与修复分子医学重点实验室,河南洛阳 471003
- Keywords:
microRNA;
hepatocellular carcinoma;
tumor regulation;
biomarker;
therapeutic target
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(8):1231-1235
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)accounts for more than 80％of primary liver cancer,and the prognosis of patients is very poor due to factors such as untimely diagnosis,failure of chemotherapy and frequent recurrence.MicroRNA is a kind of endogenous noncoding RNA,which can inhibit the translation of messenger RNA in liver malignant tumors,regulate the proliferation,apoptosis,migration and invasion of HCC cells,and play an important role in the development of HCC.Therefore,the mechanism of miRNAs in the development of HCC and its research progress in diagnosis and treatment are deeply discussed.
