Research status of the role of remimazolam in improving cognitive function during perioperative period

VernacularTitle:瑞马唑仑在围术期改善认知功能作用的研究现状
Author: Jin-Xin LAN ¹ ; Sen LI ; Duo YANG ; Jun-Bing HE ; Long-Sheng ZHANG
Author Information

1. 广东医科大学第一临床医学院,广东湛江 524023;揭阳市人民医院麻醉科,广东揭阳 522000
Keywords: remimazolam; cognitive function; inflammation
From: The Chinese Journal of Clinical Pharmacology 2024;40(5):773-777
CountryChina
Language:Chinese
Abstract: Postoperative cognitive dysfunction(POCD)is one of the common complications in the perioperative period,and it has a high incidence in elderly patients,and the large production of neuroinflammatory factors under surgical stimulation is the main cause of postoperative POCD.As an ultra-short-acting benzodiazepine of γ-aminobutyric acid receptor agonist,remimazolam can play a sedative-hypnotic and anxiolytic role in clinical practice,and can reduce inflammatory factors in the central nervous system and improve postoperative cognitive dysfunction by inhibiting neuroinflammatory response and oxidative stress.This article reviews the protective effect and mechanism of remimazolam on postoperative cognitive function,so as to provide a basis for the clinical use of remimazolam.