Preliminary study on treatment of local digestive tract diseases in children with octreotide injection through"oral administration"
10.13699/j.cnki.1001-6821.2024.05.009
- VernacularTitle:奥曲肽注射液经"口服给药"治疗儿童消化道局部疾病的探索
- Author:
Miao HE
1
;
Yong-Mei XIE
;
Zhi-Ling WANG
Author Information
1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,四川成都 610041;九○三医院儿科,四川江油 621700
- Keywords:
octreotide;
somatostatin;
oral administration;
subcutaneous injection;
children;
blood concentration
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(5):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of octreotide injection for"oral administration"in children.Methods The acid resistance stability experiment was divided into experimental group(dissolve octreotide in hydrochloric acid at pH 4.0-4.5)and control group(dissolve octreotide in 0.9％NaCl at pH 7.0-7.5).BN juvenile rats were randomly assigned to the subcutaneous injection group of octreotide(12 μg·kg-1·d-1,subcutaneous injection),the oral administration group of octreotide(12 μg·kg-1·d1-1,oral administration),and the control group(0.9％NaCl)based on gender and body mass grading,with 10 rats in each group.Collect blood samples from 2 children with refractory diarrhea after subcutaneous injection and oral administration of octreotide for 1 hour,and monitor the plasma concentration.Compare the differences in plasma and gastrointestinal concentrations in rats,as well as the differences in plasma concentration in two pediatric patients.Measure the plasma concentration of octreotide using radioimmunoassay.Detection of octreotide concentration in rat intestine by immunohistochemical method.Results The concentrations of octreotide in the experimental group and control group were(810.71±1.91)and(816.55±5.60)ng·mL-1,respectively,without statistically significant difference(P＞0.05).The integrated optical density(IOD)values of octreotide in the subcutaneous injection group and oral administration group were 6.84±0.88 and 9.82±1.07;the concentrations of octreotide in peripheral blood were(26.07±12.19)and(3.53±0.76)ng·mL-1,with statistical significance(all P＜0.001).The plasma concentration of octreotide administered orally and subcutaneously in two pediatric patients were 2.52-3.30 and 22.36-31.68 ng·mL-1.Conclusion"Oral administration"of octreotide exhibits a distribution of"high gastrointestinal concentration/low plasma concentration".High gastrointestinal concentration can treat local gastrointestinal diseases in children and avoid injection pain.Oral administration of low plasma concentration is beneficial for reducing systemic adverse drug reactions in children with growth inhibition.
