A novel self-assembly lymphatic tracer—"mitoxantrone hydrochloride injection for tracing"
10.13699/j.cnki.1001-6821.2024.04.029
- VernacularTitle:新型淋巴示踪剂—示踪用盐酸米托蒽醌注射液
- Author:
Gang LANG
1
;
Xin-Yi LI
;
Shu-Jun WANG
Author Information
1. 深圳华润九新药业有限公司,深圳广东 518049
- Keywords:
mitoxantrone hydrochloride injection for tracing;
nanocrystals;
lymphatic tracer;
breast cancer;
thyroid cancer
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(4):615-618
- CountryChina
- Language:Chinese
-
Abstract:
Standardized lymph node dissection is the key to radical surgery for malignant tumors.However,the choice of lymphatic tracers in China is limited at present.After years of research and development,the team of Shujun Wang from Shenyang Pharmaceutical University has innovatively developed the first biological self-assembly nanocrystal lymphatic targeted tracer——mitoxantrone hydrochloride injection for tracing.After preclinical animal studies and phase Ⅰ-Ⅲ clinical studies,the drug was approved for marketing in China in June 2021 and it has been widely used in lymph node dissection for thyroid cancer and sentinel lymph node biopsy for breast cancer.Its efficacy and safety have been clinically verified.This article expounds the mechanism of action,method of application,efficacy and safety,pharmacokinetics,and differences from traditional mitoxantrone used in chemotherapy,so as to provide a reference for the clinical application of mitoxantrone hydrochloride injection for tracing.
