Effects of astragalus polysaccharide on proliferation and invasion of triple negative breast cancer cells

VernacularTitle:基于生物信息学分析三阴性乳腺癌的差异表达基因和药物靶点挖掘
Author: Yan LI ¹ ; Xing-He WANG
Author Information

1. 首都医科大学附属北京世纪坛医院药物Ⅰ期临床试验研究室,北京 100038
Keywords: triple negative breast cancer; bioinformatics; differential gene; drug target
From: The Chinese Journal of Clinical Pharmacology 2024;40(2):269-272
CountryChina
Language:Chinese
Abstract: Through biological analysis of breast cancer data in gene expression omnibus(GEO),The Cancer Genome Atlas(TCGA)and other databases,this study screened the differentially expressed genes in triple-negative breast cancer compared with other breast cancer subtypes,so as to mine drug targets according to its characteristics and provide some reference for the identification and prognosis of triple-negative breast cancer.Based on the analysis of bio-informatics,it showed that triple negative breast cancer has characteristic manifestations in the process of cell cycle and estrogen signaling pathway.The screened 10 hub genes can better predict and diagnose triple negative breast cancer.The drug targets exploring rusults suggest that pyrazolanthrone,alvocidib and so on are potential drugs which have research and development value.