Clinical analysis of Castleman's disease
10.13699/j.cnki.1001-6821.2017.23.036
- VernacularTitle:Castleman病的临床研究
- Author:
Hai-Long YUAN
1
;
Aizezi · GULIBADANMU
;
Jian-Hua QU
;
Hai-Zhou CAO
;
Xian-Lin DUAN
;
Jian-Li XU
;
Gang CHEN
Author Information
1. 新疆医科大学第一附属医院血液病中心,乌鲁木齐830054
- Keywords:
Castleman's disease;
human herpesvirus type 8;
treatment;
prognosis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2446-2448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations,pathological characteristics,treatment and outcome of Castleman's disease (CD).Methods Retrospective analysis of clinical manifestations,laboratory examination,pathology and treatment of 10 patients with CD from March 2011 to May 2014 in our hospital was performed.Results 4 cases were males,6 cases were females,with a median age of 44 years (30-71 years old).1 case was unicentric Castleman's disease (UCD),9 cases were multicentric Castleman's disease (MCD).3 cases were hyaline-vascular type and 7 cases in plasma cell type according to pathological classification,non mixed type.1 UCD case with HV type acquired remission after surgery.One case of MCD did not receive chemotherapy,eight cases were received chemotherapy,including one case of complete remission,6 cases of stable disease,one case of disease progression.None of the patients were transferred into lymphoma.The median follow-up time was 26.5 months (from 13 to 64 months),1 patient died,3-year probabilities overall survival was 84.3％.Conclusion CD had various symptoms and signs.It was diagnosed by pathology.The UCD was often asymptomatic and curable by surgical excision of the mass,while MCD had a less favorable prognosis by chemotherapy and chemotherapy combined with monoclonal antibodies.
