Comparative study on the interleukin-10 and tumor necrosis factor-α level in the pulmonary tuberculosis patients of Uygur and Han population in Xinjiang
10.13699/j.cnki.1001-6821.2017.22.005
- VernacularTitle:新疆维吾尔族和汉族肺结核患者白细胞介素-10及人肿瘤坏死因子-α表达水平的比较研究
- Author:
Xiao-Yi WANG
1
;
Song-Song XIE
;
Li CHENG
;
Guo-Chang LI
;
Xin-Chun WANG
Author Information
1. 石河子大学医学院第一附属医院药剂科
- Keywords:
Han population;
Uygur population;
pulmonary tuberculosis;
tumor necrosis factor-α;
interleukin-10
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(22):2230-2232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of human tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in the serum of Han and Uygur tuberculosis (TB) patients,and to analyze the relationship between sexes.Methods A total of 132 Han patients and 122 Uygur patients with TB were enrolled in this study.The levels of TNF-α and IL-10 in serum were measured by commercially available enzyme linked immune-sorbent assay (ELISA).Results The serum TNF-α of the Han and Uygur patients were (21.72 ±7.18),(29.86 ±8.61)pg · mL-1;IL-10 levels in the Han and Uygur patients were (34.90±11.18) pg·mL-1,(41.65±18.11) pg· mL-1.There were significant differences between the Han and the Uygur patients (P ＜0.05).The concentration of serum IL-10 in male and female patients were (44.93 ± 18.56),(38.95 ± 13.13) pg · mL-1,and significant difference was found between the two genders (P ＜ 0.05) in Uygur,while there was no significant difference in TNF-α.Moreover,no significant difference was found in IL-10 and TNF-α between the two genders in Han patients.Conclusion There were significant differences in the serum TNF-α and IL-10 between the Han and the Uygur patients,while significant difference was also found in the serum TNF-α between the two genders in Han and Uygur TB patients.
