Pharmacokinetics of dimemorfan phosphate syrups in healthy Chinese volunteers
10.13699/j.cnki.1001-6821.2015.12.018
- VernacularTitle:磷酸二甲啡烷糖浆剂在中国健康受试者的药代动力学
- Author:
Ye HUA
1
;
Qi PEI
;
Hong-Yi TAN
;
Cheng-Xian GUO
;
Liu YANG
;
Jun CHEN
;
Jin-Fu PENG
;
Jie HUANG
;
Guo-Ping YANG
Author Information
1. 中南大学药学院
- Keywords:
dimemorfan;
healthy volunteer;
pharmacokinetics;
HPLC-MS/MS
- From:
The Chinese Journal of Clinical Pharmacology
2015;(12):1136-1139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacokinetics of dimemor-fan phosphate syrups at single dose or multiple doses in healthy Chinese volunteers.Methods Twelve healthy volunteers were selected, six males and six females.Single doses of dimemorfan phosphate syrups(10, 20, 40 mg) were given, and then multiple doses of 20 mg were given three times a day for four days.The concentrations of dimemorfan in plas-ma were determined by high performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS).Results The main pharmacoki-netic parameters of dimemorfan after single dose (10, 20, 40 mg) were as follows:Cmaxwas (0.94 ±0.44), (2.19 ±1.40)and (5.30 ±4.83)μg? L-1 , AUClast was ( 11.06 ±5.74 ) , ( 26.41 ±18.08 ) and (53.78 ±38.28)μg? L-1? h, AUCinf was (12.14 ±6.02), (28.46 ± 20.21)and(57.26 ±41.40)μg? L-1? h.The parameters of dimemor-fan after multiple doses 20 mg were as follows:Cmax was (5.57 ±3.64)μg? L-1, AUClast was (83.07 ±62.51)μg? L -1? h, and AUCinf was (88.54 ±68.14)μg? L-1? h.Conclusion After the administration of single dose (10, 20, 40 mg), the pharmacokinetic results show that dimemorfan exhibits first order kinetic characteristics.After administration of multiple doses, the accumulation factor value was nearly three and dimemorfan shows a linear accumulation.
