Pharmacokinetic/pharmacodynamic study of tebipenem pivoxil against Klebsiella pneumoniae in murine lung infection model
10.13699/j.cnki.1001-6821.2015.04.011
- VernacularTitle:泰比培南酯对小鼠肺炎克雷伯菌肺部感染模型的药代动力学/药效学研究
- Author:
Shan SU
1
;
Xiang-Dong CHEN
;
Hui WANG
;
Cong GAO
;
Rui-Xue LV
Author Information
1. 中国药科大学 生命科学与技术学院 微生物教研室
- Keywords:
tebipenem pivoxil;
Klebsiella pneumoniae;
lung infection model;
PK/PD
- From:
The Chinese Journal of Clinical Pharmacology
2015;(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the pharmacokinetic/pharmacody-namic ( PK/PD ) parameters that predict tebipenem pivoxil efficacy against Klebsiella pneumoniae in murine lung infection model. Methods The minimal inhibitory concentration ( MIC ) of tebipenem pivoxil against Klebsiella pneumoniae was determined by standard two-fold agar dilution method.Three doses of 50, 15 and 3mg? kg-1 were given to lung infection models, respectively.The bacterial burden in lung was measured 24 hours after the initiation of treatment and the concentra-tion in plasma was determined by high performance liquid chromatogra-phy ( HPLC) .Results The MIC value was 0.03 μg? mL-1 .Three doses all showed effects on murine lung infection model.Three PK/PD parameters correlated with efficacy of tebipenem pivoxil were AUC/MIC ( r =0.78 ) , Cmax/MIC ( r =0.76 ) , and T >MIC ( r =0.46 ) . Conclusion PK/PD study indicates AUC/MIC and Cmax/MIC are PK/PD parameters, well correlated with the efficacy of tebipenem pivoxil against Klebsiella pneumoniae in murine lung infection model.
