Injection of platelet-rich plasma at the fracture site combined with microfracture surgery for the treatment of delayed fracture healing
10.13303/j.cjbt.issn.1004-549x.2025.02.006
- VernacularTitle:骨折端富血小板血浆注射联合微骨折术治疗骨折延迟愈合的临床应用观察
- Author:
Junbo TU
1
;
Xiaowu HUANG
1
;
Xingwang LI
1
;
Xiaoqing LI
2
Author Information
1. Department of Orthopaedics
2. Department of Blood Transfusion, XinFeng County People’s Hospital, Ganzhou 341600, China
- Publication Type:Journal Article
- Keywords:
platelet-rich plasma (PRP);
microfracture surgery;
delayed fracture union
- From:
Chinese Journal of Blood Transfusion
2025;38(2):194-200
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To report a new technique that combines microfracture surgery under local anesthesia with injection of platelet-rich plasma (PRP) at the fracture site, so as to improve fracture healing rates. [Methods] Data from patients who visited our hospital from March 2020 to June 2023 and underwent the treatment for delayed union of limb fractures were retrospectively analyzed. Under local infiltrative anesthesia, with the assistance of a C-arm X-ray machine or ultrasound, percutaneous loosening was done at the fracture site and the medullary cavity, followed by cortical drilling around the fracture. The previously prepared PRP was then injected locally at the fracture site. Patients were followed up and their postoperative recovery was recorded. [Results] All patients were followed up, and the fracture healing rate was 94.12% (16/17), with an average healing duration of (5.88±2.50) months. None of the patients experienced any neural or vascular injuries, nor adverse events such as wound infections or osteomyelitis. Before the operation and at the last follow-up, the patients' pain visual analogue scores were (5.12±1.11) vs (0.71±1.21) respectively. The postoperative VAS scores showed a significant decrease compared to preoperative values (P<0.05). The excellent and good rate for limb function on the affected side was 88.24% (14/17) at the last follow-up, which was a significant increase from 0.00% before surgery (P<0.05). [Conclusion] The injection of PRP at the fracture site combined with microfracture surgery at the fracture site is minimally invasive, simple to perform, and well-accepted by patients. It has demonstrated some clinical efficacy in treating delayed fracture healing.
