Effectiveness of platelet-rich plasma separation technique in total aortic arch replacement
10.13303/j.cjbt.issn.1004-549x.2025.02.005
- VernacularTitle:主动脉全弓置换术中自体富血小板血浆分离技术的有效性研究
- Author:
Chao PANG
1
;
Shaopeng ZHANG
2
;
Yunpeng BAI
2
;
Shuhua XIE
1
Author Information
1. Department of Anesthesiology, Tianiin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin 300121, China
2. Chest Hospital of Tianjin University, Tianjin Cardiovascular Disease Research Institute, Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin 300222, China
- Publication Type:Journal Article
- Keywords:
aortic dissection;
blood transfusion;
platelet-rich plasma
- From:
Chinese Journal of Blood Transfusion
2025;38(2):189-193
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To evaluate the efficacy and practicality of autologous platelet-rich plasma (aPRP) in patients undergoing total aortic arch replacement for aortic dissection. [Methods] A retrospective analysis was performed on 483 patients diagnosed with type A aortic dissection who underwent total aortic arch replacement between January 2016 and November 2023. Patients were categorized into two groups based on whether they received aPRP. Baseline characteristics, intraoperative blood product usage and postoperative outcomes were compared between the two groups. [Results] The aPRP group exhibited reduced usage of allogeneic platelets (1.55±1.04 vs 1.60±1.27)U, allogeneic plasma (480.89±432.49 vs 746.50±508.81)mL, allogeneic RBC (red blood cell)(5.95±1.91 vs 6.17±3.52)U, bivalirudin (2.66±1.51 vs 3.31±1.59)U and coagulation factor Ⅶ (0.67±1.03 vs 1.22±1.43)mg compared to the non-aPRP group (P<0.05). The incidence of postoperative hypoxemia was lower in the aPRP group (43.98% vs 48.41%), and the duration of mechanical ventilation was significantly shorter[median 50.91 (interquartile range 18.71, 113.71) vs 83.40 (37.73, 151.98) hours]. There were no significant differences between the two groups in terms of postoperative mortality, continuous bedside hemofiltration, cerebral infarction, cerebral hemorrhage, paraplegia or re-exploration for hemostasis(P>0.05). [Conclusion] The application of aPRP in total aortic arch replacement effectively diminishes intraoperative blood product usage and the incidence of lung injury-related complications. However, it does not demonstrate significant benefits in terms of mortality, cerebral infarction and other complications.
