Role of triggering receptor expressed on myeloid cells 2 in acute and chronic liver diseases

Xinyue CUI; Quanhao SUN; Lihong ZHENG; Haiqiang WANG

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Role of triggering receptor expressed on myeloid cells 2 in acute and chronic liver diseases

VernacularTitle:髓系细胞触发受体2（TREM2）在急慢性肝病中的作用
Author: Xinyue CUI ¹ ; Quanhao SUN ¹ ; Lihong ZHENG ² ; Haiqiang WANG ³
Author Information

1. The First Clinical College of Heilongjiang University of Chinese Medicine， Harbin 150040， China
2. Department of Gastroenterology， The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine， Harbin 150001， China
3. Second Department of Gastroenterology， The First Affiliated Hospital of Heilongjiang University of Chinese Medicine， Harbin 150040， China
Publication Type:Review
Keywords: Triggering Receptor Expressed on Myeloid Cells 2; Liver Diseases; Pathologic Processes
From: Journal of Clinical Hepatology 2025;41(2):383-388
CountryChina
Language:Chinese
Abstract: Triggering receptor expressed on myeloid cells 2 （TREM2） is expressed in resident non-parenchymal cells （NPCs） and is involved in various pathological processes including liver inflammation and immunoregulation. In recent years， TREM2 has attracted attention in the field of acute and chronic liver diseases， and more and more studies have shown that TREM2 is a potential target for the treatment of acute and chronic liver diseases； however， there is a lack of systematic summary for the mechanism of action of TREM2 in acute and chronic liver diseases. Therefore， this article reviews the latest research advances in the regulatory role of TREM2 in acute and chronic liver diseases， in order to provide new ideas for the clinical prevention and treatment of acute and chronic liver diseases.