Role of acetylation modification in the occurrence and development of thyroid cancer and its potential clinical application value
10.3872/j.issn.1007-385x.2025.01.005
- VernacularTitle:乙酰化修饰在甲状腺癌发生发展中的作用及其潜在的临床应用价值
- Author:
Nan LIANG
1
;
Qian AO
1
;
Hui SUN
1
Author Information
1. 吉林大学中日联谊医院 甲状腺外科,吉林省外科转化医学重点实验室,吉林省甲状腺疾病防治工程实验室,吉林 长春 130000
- Publication Type:Journal Article
- Keywords:
thyroid cancer;
acetylation modification;
histone deacetylase(HDAC)inhibitor;
targeted therapy
- From:
Chinese Journal of Cancer Biotherapy
2025;32(1):30-37
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid cancer is the most prevalent malignant tumor of the endocrine system,and its incidence has shown a significant upward trend in recent years.Acetylation,an important post-translational protein modification,is involved in regulating gene transcription,cell cycle progression,and invasion ability in various types of thyroid cancers.Additionally,histone deacetylase(HDAC)inhibitors have shown potential in the treatment of thyroid cancer.This article systematically reviews the biological functions and regulatory mechanisms of acetylation in the development and progression of thyroid cancer based on recent literature.Furthermore,it discusses the clinical application prospects of HDAC inhibitors,providing a solid theoretical basis and feasible therapeutic strategies for targeted therapy of thyroid cancer.
