Role of acetylation modification in the occurrence and development of thyroid cancer and its potential clinical application value
DOI：10.3872/j.issn.1007-385x.2025.01.005
- VernacularTitle:乙酰化修饰在甲状腺癌发生发展中的作用及其潜在的临床应用价值
- Author:
LIANG Nan
1
;
AO Qian
1
;
SUN Hui
1
Author Information
1. (Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun 130000, Jilin, China)
- Publication Type:Journal Article
- Keywords:
甲状腺癌；乙酰化修饰；组蛋白去乙酰化酶抑制剂；靶向治疗
- From:
Chinese Journal of Cancer Biotherapy
2025;32(1):30-37
- CountryChina
- Language:Chinese
-
Abstract:
[摘 要] 甲状腺癌是内分泌系统中最为常见的恶性肿瘤，近年来其发病率呈现出显著的上升趋势。乙酰化修饰作为一种重要的蛋白质翻译后修饰，参与调控各个类型甲状腺癌相关基因的转录表达、细胞周期进程及侵袭能力。组蛋白去乙酰化酶（HDAC）抑制剂在甲状腺癌治疗中显示出潜在的应用前景。本文通过调研近年来相关文献，系统回顾了乙酰化修饰在参与甲状腺癌发生发展过程中的生物学功能及其调控机制，进一步探讨HDAC抑制剂在临床治疗中的应用前景，为甲状腺癌的靶向治疗提供坚实的理论依据和提出可行的治疗策略。
- Full text:202502281543382404520250105.pdf
