Construction of heparin sulfate/chitosan antibacterial polyelectrolyte membrane loaded with silver on titanium surface
10.19405/j.cnki.issn1000-1492.2022.05.015
- Author:
Jiaojiao Li
1
;
Zhang′ao Wei
1
;
Weibo Zhang
1
;
Xiangyang Li
1
;
Jialong Chen
1
Author Information
1. Teaching and Research Section of Dental Materials , Stomatological College of Anhui Medical University, The Afiliated Stomatological Hospital of Anhui Medical University, Anhui Province Key Laboratory of Oral Diseases Research ,Hefei 230032
- Publication Type:Journal Article
- Keywords:
titanium;
layer⁃by⁃layer self⁃assembly;
silver;
antibacterial
- From:
Acta Universitatis Medicinalis Anhui
2022;57(5):754-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the antibacterial properties of nano-silver-containing polyelectrolyte multilayer films assembled with heparan sulfate(HEP) and chitosan(CHI) by layer-by-layer self-assembly technology(LBL) on porous titanium surface.
Methods:Negatively charged HEP and positively charged CHI were alternately adsorbed by LBL to form polyelectrolyte multilayer films, which were deposited on the surface of porous titanium, and then silver ions were loaded on the multilayer films under alkaline conditions. The surface was evaluated by scanning electron microscopy, X-ray photoelectron spectrometer, a measuring instrument for contact angle and inductively coupled plasma emission spectrometer. The antibacterial effect was evaluated by inhibition zone, turbidity method, live/dead bacterial staining and coated plate method.
Results:Material characterization methods showed polyelectrolyte multilayer films were successfully deposited on the surface of titanium, and nano-silver particles were loaded. Antibacterial experiments showed that the silver-loaded modification significantly improved the antibacterial ability of the coating.
Conclusion:Silver-loaded HEP-CHI polyelectrolyte multilayer films are deposited on the surface of modified titanium by LBL, which can inhibit the adhesion of bacteria.
- Full text:2025021915575254445钛表面载银的硫酸乙酰肝素_壳聚糖抗菌涂层的构建_李娇娇.pdf
