The value of left ventricular spherical index in predicting the prognosis of dilated cardiomyopathy
10.19405/j.cnki.issn1000-1492.2022.04.028
- Author:
Hongli Chen
1
;
Hui Huang
2
;
Zhong Wang
2
Author Information
1. Dept of Clinical Medicine，School of Medicine，Shihezi University，Shihezi 832000
2. Dept of Cardiology，First Affiliated Hospital，School of Medicine，Shihezi University，Shihezi 832000
- Publication Type:Journal Article
- Keywords:
left ventricular spherical index;
dilated cardiomyopathy;
heart failure
- From:
Acta Universitatis Medicinalis Anhui
2022;57(4):655-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of left ventricular spherical index(LVSI) in prognosis of patients with dilated cardiomyopathy(DCM).
Methods:The DCM patients from hospital were included. All DCM patients were treated with standard anti-heart failure drugs and followed up for six months. They were divided into a good prognosis group according to whether adverse cardiovascular events(MACE) occurred(n=77) and poor prognosis group(n=154). All patients′ age, course of disease, body mass index(BMI), blood pressure, N-terminal fragment of the BNP precursor(NT-proBNP), echocardiogram indicators and other clinical data were collected, and the drug consumption during the follow-up period and the occurrence of MACE events were recorded. Binomial logistic regression was used to analyze the risk factors of MACE events in DCM patients, and receiver operating characteristic(ROC) curves were used to analyze the predictive value of LVSI for MACE events in DCM patients.
Results:Compared with the good prognosis group, the patients in the poor prognosis group had a longer course of disease, faster heart rate, and increased NT-proBNP, left atrium diameter(LAD), left ventricular end diastolic diameter(LVEDd), and LVSI; systolic blood pressure and left ventricular ejection fraction(LVEF) decreased(P<0.001), and other indicators had no statistical difference. The results of binomial logistic regression analysis showed that the duration of heart failure(OR=1.187,95% CI:1.091-1.290, P<0.001), admission systolic blood pressure(OR=2.089, 95%CI:1.243-3.510,P=0.005), LVEDd(OR=1.241, 95%CI:1.080-1. 426,P = 0. 002),LVEF( OR = 0. 862,95% CI: 0. 771-0. 963,P = 0. 009),LVSI( OR = 1. 462,95% CI:1. 262-1. 693,P<0. 001),NT-proBNP( OR = 1. 001,95% CI: 1. 000-1. 001,P = 0. 002) were independent predictors of MACE in DCM patients. LVSI of 61. 95% was the best critical value for predicting the occurrence of MACE. At this time,the area under the ROC curve was 0. 821( 95% CI: 0. 769-0. 874,P<0. 001),the maximum Youden index was 0. 461,and the sensitivity: 0. 695,specificity: 0. 766.
Conclusion:LVSI,LVEDd,LVEF,heart failure course,admission systolic blood pressure,NT-proBNP are the prognostic factors of DCM patients. The left ventricular spherical index has a certain predictive effect on the prognosis of DCM patients.
- Full text:2025021908175048372左心室球形指数对扩张型心肌病预后预测价值的研究_陈红莉.pdf
