Uric acid-lowering activity and mechanisms of Chinese medicines with medicine-food homology:a systematic study
10.1016/j.dcmed.2025.01.004
- VernacularTitle:药食同源中药降尿酸活性及其作用机制的系统研究
- Author:
Fengyi QIN
1
;
Yishuo ZHU
;
Lewei ZHAO
;
Siyu CHEN
;
Zhixing QING
Author Information
1. 湖南农业大学动物医学院,湖南 长沙 410128,中国
- Publication Type:Journal Article
- Keywords:
Hyperuricemia(HUA);
Medicine food homology;
Chinese medicine;
Active compounds;
Extract
- From:
Digital Chinese Medicine
2024;7(4):405-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the uric acid-lowering effects and mechanisms of Chinese medicines with medicine-food homology,aiming to provide novel perspectives for the devel-opment of new anti-hyperuricemia(HUA)drugs.Methods Papers on the research of HUA prevention and treatment with medicine-food ho-mology from December 15,2002 to August 10,2024 were screened and collected through Chi-na National Knowledge Infrastructure(CNKI),PubMed,ScienceDirect,and Google Scholar.Subsequently,the impact of these medications and their extracts,as well as the active com-pounds on HUA were assessed.Results A total of 148 relevant papers were collected,including 43 kinds of Chinese medicines and 61 active compounds,all of which have anti-HUA activity.Among them,41 kinds of Chinese medicines could inhibit the activity of xanthine oxidase,thus leading to the inhibition of uric acid production;and 22 kinds of Chinese medicines could facilitate uric acid excretion,while 15 kinds of Chinese medicines could reduce the inflammation levels in the body and promoting renal protection.Notably,polyphenols and flavonoids are the key active components for the uric acid-lowering effects.Conclusion This study systematically summarized and analyzed the uric acid-lowering ef-fects and mechanisms of Chinese medicines with medicine-food homology,laying a founda-tion for their development as HUA agents.
