Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori
10.12290/xhyxzz.2023-0341
- VernacularTitle:幽门螺杆菌诱导上皮-间质转化在胃癌中的作用机制
- Author:
Zhencan SUN
1
;
Jukun ZHOU
1
;
Yunpeng XU
2
;
Jun WANG
3
;
Ya ZHENG
4
;
Yuping WANG
4
;
Rui JI
5
Author Information
1. The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, China;Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;
2. The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, China;
3. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Digestive Endoscopy Center, the First Hospital of Lanzhou University, Lanzhou 730000, China;
4. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China;
5. Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China;Digestive Endoscopy Center, the First Hospital of Lanzhou University, Lanzhou 730000, China;Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China;
- Publication Type:Review
- Keywords:
Helicobacter pylori;
epithelial-mesenchymal transition;
gastric cancer;
cytotoxin-associated gene A;
mesenchymal stem cells
- From:
Medical Journal of Peking Union Medical College Hospital
2024;15(1):160-165
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) is a unipolar, microaerobic, multiflagellar, spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa. As a classⅠcarcinogen associated with gastric cancer, long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It has been reported that Hp can cause epithelial-mesenchymal transition (EMT) in gastric epithelial cells, thereby inducing gastric cancer. We review the mechanism of Hp-induced EMT in gastric epithelial cells, in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.
