Research progress on the interaction between immunosuppressants and intestinal flora after liver transplantation
- VernacularTitle:肝移植后免疫抑制剂与肠道菌群相互作用的研究进展
- Author:
Saijuan LU
1
;
Cangsang SONG
1
;
Xingde LI
1
;
Guohui WANG
2
;
Panpan MAO
2
Author Information
1. Dept. of Pharmacy，Kunming First People’s Hospital，Kunming 650224，China;Dept. of Pharmacy，Calmette Hospital Affiliated to Kunming Medical University，Kunming 650224，China
2. Dept. of Pharmacy，Kunming First People’s Hospital，Kunming 650224，China
- Publication Type:Journal Article
- Keywords:
immunosuppressant;
intestinal flora;
liver transplantation;
tacrolimus;
cyclosporin;
mycophenol ester;
glucocorticoid
- From:
China Pharmacy
2025;36(3):362-366
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressants （including cyclosporine， tacrolimus， mycophenolate esters， glucocorticoids， etc.） are the first choice of drugs to prevent organ rejection after liver transplantation， which can effectively reduce the host immune response to the graft， improve the success rate of transplantation， and prolong the survival of patients. Liver transplantation is associated with intestinal flora， while immunosuppressive agents interact with intestinal flora. Immunosuppressive agents change the abundance， composition and metabolites of intestinal flora， while a series of enzymes and metabolites produced by intestinal flora may chemically alter the absorption and metabolism of immunosuppressants. In addition， the incidence of postoperative infection in liver transplantion patients is relatively high， while gut flora affects inflammatory factors， and immunosuppressants interact with inflammatory factors. To some extent， immunosuppressants can be thought of as acting through intestinal flora in patients after liver transplantation.
