Literature analysis of cardiotoxicity caused by lidocaine
10.6039/j.issn.1001-0408.2025.02.13
- VernacularTitle:利多卡因致心脏毒性的文献分析
- Author:
GULINIGEER·AINIWAER
1
;
Mingxia CHENG
;
Han XIE
Author Information
1. 中国药科大学南京鼓楼医院药学部,南京 210008;中国药科大学基础医学与临床药学学院,南京 210009
- Publication Type:Journal Article
- Keywords:
lidocaine;
cardiotoxicity;
anesthetic;
safety of drug use;
literature analysis
- From:
China Pharmacy
2025;36(2):208-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical characteristics of cardiotoxicity caused by lidocaine,and provide a reference for the safe use of drug in clinical practice.METHODS Chinese and English search terms,such as"lidocaine""cardiotoxicity",were used to search for literature related to lidocaine-induced cardiac toxicity from CNKI,Wanfang Data,VIP,PubMed and Embase,and conduct descriptive analysis.RESULTS A total of 31 papers were included,with 40 patients.Of the 40 patients,23 were male and 17 were female;ages ranged from 5 months to 73 years,with 4 patients≤18 years old,17 patients 19-59 years old,and 19 patients≥60 years old.The main indications for medication were surgical anesthesia(26 cases),and the main routes of administration were intravenous administration,nerve block anesthesia and local infiltration anesthesia(15,6,6 cases);the dosage of medication for 34 patients complied with the instructions;the most of cardiotoxicity occurred 1 min-1 h after medication(19 cases),and the main symptoms were bradycardia,atrial conduction slowing,atrioventricular block,sinus arrest,etc.Thirty-four patients improved after resuscitation and symptomatic treatment,and six patients died.CONCLUSIONS Lidocaine-induced cardiotoxicity can occur in all ages,mainly within 1 h after administration,and is manifested as arrhythmia,tachycardia or tachycardia,atrioventricular block,etc.,which is severe.When using it clinically,it is necessary to strengthen pharmaceutical monitoring of medication dosage,administration route,toxic reactions,etc.;when relevant symptoms appear,medication should be stopped promptly and symptomatic treatment should be carried out,to protect the safety of drug use.
