Literature analysis of cardiotoxicity caused by lidocaine
- VernacularTitle:利多卡因致心脏毒性的文献分析
- Author:
Ainiwaer GULINIGEER
1
;
Mingxia CHENG
2
;
Han XIE
3
Author Information
1. Dept. of Pharmacy，Nanjing Drum Tower Hospital，China Pharmaceutical University，Nanjing 210008，China;School of Basic Medicine and Clinical Pharmacy，China Pharmaceutical University，Nanjing 210009，China
2. Nanjing Drum Tower Hospital Clinical College，Nanjing University of Chinese Medicine，Nanjing 210009，China;Dept. of Pharmacy，Nanjing Drum Tower Hospital，the Affiliated Hospital of Nanjing University Medical School，Nanjing 210008，China
3. Dept. of Pharmacy，Nanjing Drum Tower Hospital，the Affiliated Hospital of Nanjing University Medical School，Nanjing 210008，China
- Publication Type:Journal Article
- Keywords:
lidocaine;
cardiotoxicity;
anesthetic;
safety of drug use;
literature analysis
- From:
China Pharmacy
2025;36(2):208-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical characteristics of cardiotoxicity caused by lidocaine， and provide a reference for the safe use of drug in clinical practice. METHODS Chinese and English search terms， such as “lidocaine”“ cardiotoxicity”， were used to search for literature related to lidocaine-induced cardiac toxicity from CNKI， Wanfang Data， VIP， PubMed and Embase， and conduct descriptive analysis. RESULTS A total of 31 papers were included， with 40 patients. Of the 40 patients， 23 were male and 17 were female； ages ranged from 5 months to 73 years， with 4 patients≤18 years old， 17 patients 19-59 years old， and 19 patients≥60 years old. The main indications for medication were surgical anesthesia （26 cases）， and the main routes of administration were intravenous administration， nerve block anesthesia and local infiltration anesthesia （15， 6， 6 cases）； the dosage of medication for 34 patients complied with the instructions； the most of cardiotoxicity occurred 1 min-1 h after medication （19 cases）， and the main symptoms were bradycardia， atrial conduction slowing， atrioventricular block， sinus arrest， etc. Thirty- four patients improved after resuscitation and symptomatic treatment， and six patients died. CONCLUSIONS Lidocaine-induced cardiotoxicity can occur in all ages， mainly within 1 h after administration， and is manifested as arrhythmia， tachycardia or tachycardia， atrioventricular block， etc.， which is severe. When using it clinically， it is necessary to strengthen pharmaceutical monitoring of medication dosage， administration route， toxic reactions， etc.； when relevant symptoms appear， medication should be stopped promptly and symptomatic treatment should be carried out， to protect the safety of drug use.
