Two sample Mendelian randomization analysis of the causal relationship between relative intake of four constant nutrients and kidney stones
10.3969/j.issn.1009-8291.2024.12.011
- VernacularTitle:两样本孟德尔随机化分析4种常量营养素相对摄入量与肾结石的因果关系
- Author:
Cong WANG
1
;
Yujia XI
1
;
Zhenxing WANG
2
;
Yijun JIA
1
;
Chuan HAO
2
Author Information
1. The Second Clinical Medical College, The Second Hospital, Shanxi Medical University, Taiyuan 030001, China; Department of Urology, The Second Hospital, Shanxi Medical University, Taiyuan 030001, China
2. Department of Urology, The Second Hospital, Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
kidney stones;
diet;
carbohydrate;
added sugar
- From:
Journal of Modern Urology
2024;29(12):1081-1087
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the causal relationship between the relative intake of dietary components (including carbohydrate, added sugar, protein, and fat) and kidney stones using two sample Mendelian randomization (MR). [Methods] The genetic instrumental variables (IVs) from genome-wide association study (GWAS) statistics, exposure-related summary data from the SSGAC genome study, and kidney stone data from the Finn Gen Consortium were collected, which were then analyzed with inverse variance weighting (IVW). The MR results and sensitivity were assessed with MR-Egger, weighted median, MR-PRESSO test, Cochran's Q test, leave-one analysis, and Steiger filter. [Results] IVW results showed that the relative intake of carbohydrate (OR=2.01, 95%CI: 1.02-3.96, P=0.042) and added sugar (OR=2.07, 95%CI: 1.00-4.29, P=0.049) had a causal relationship and were risk factors for the development of kidney stones.Relative intake of protein (OR=0.70, 95%CI: 0.38-1.29, P=0.249) and fat (OR=0.79, 95%CI: 0.27-2.35, P=0.671) were not associated with kidney stones.Sensitivity analysis showed no heterogeneity or pleiotropy (P>0.05). [Conclusion] Relative intake of carbohydrate and added sugar are risk factors for kidney stones, suggesting that limiting carbohydrate and added sugar intake may prevent the development of kidney stones.
