Research progress of SIRT1 in ophthalmic diseases
10.3980/j.issn.1672-5123.2025.2.08
- VernacularTitle:SIRT1在眼科疾病中的研究进展
- Author:
Yanyan YU
1
;
Zhenzhen JI
1
;
Zhijian LI
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China; Department of Ophthalmology, Heilongjiang Sengong General Hospital, Harbin 150000, Heilongjiang Province, China
- Publication Type:Journal Article
- Keywords:
sirtuin 1(SIRT1);
ophthalmic diseases;
apoptosis;
oxidative stress;
inflammation;
senescence
- From:
International Eye Science
2025;25(2):225-229
- CountryChina
- Language:Chinese
-
Abstract:
The sirtuin 1(SIRT1)is an important NAD+-dependent deacetylase that has attracted much attention in ophthalmic research in recent years. This is because the expression of SIRT1 in ocular tissues and its function are inextricably linked to the pathogenesis and progression of many ocular diseases, including dry eye, glaucoma, cataract and diabetic retinopathy. Through in-depth investigations, we have found that SIRT1, as a key regulatory protein, has a profound impact on the pathophysiological processes of ocular diseases through a variety of mechanisms, such as regulating apoptotic programs, modulating oxidative stress, mediating inflammatory responses and maintaining normal mitochondrial function. These findings indicate that SIRT1 plays an important protective role in ocular diseases. The aim of this article is to comprehensively review the latest research findings on SIRT1 in ophthalmic diseases in recent years, and hopes to provide new ideas and methods for the prevention and treatment of ophthalmic diseases by thoroughly analyzing the mechanism of action of SIRT1.
