Advances in individualized dosing models of tacrolimus for children
- VernacularTitle:儿童他克莫司个体化给药模型的研究进展
- Author:
Li SHEN
1
;
Zhiping LI
1
Author Information
1. Dept. of Clinical Pharmacy，Children’s Hospital of Fudan University/National Children’s Medical Center，Shanghai 201102，China
- Publication Type:Journal Article
- Keywords:
tacrolimus;
individualized dosing;
dosing model;
children;
organ transplantation;
pharmacokinetics
- From:
China Pharmacy
2025;36(1):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Tacrolimus is a crucial therapeutic drug for preventing immune rejection after solid organ transplantation in children. Due to the narrow treatment window and significant individual variability， personalized treatment is often required. In recent years， with the promotion of therapeutic drug monitoring technology， individualized treatment models based on tacrolimus drug concentration have developed rapidly. This article reviews the research progress of individualized dosing models for tacrolimus in children both domestically and internationally over the past decade. It includes dose simulation methods based on population pharmacokinetics， physiologically based pharmacokinetics， machine learning， and multiple linear regression. The characteristics of each model and its application in pediatric individualized dosing are analyzed and summarized. Additionally， the current development status of decision support systems for individualized tacrolimus dosing is introduced.
