Progress on effects of BaP exposure on female reproductive system and pathogenic mechanisms
- VernacularTitle:BaP暴露对女性生殖系统的影响及致病机理的研究进展
- Author:
Qianqian GAO
1
;
Xiaoling FENG
2
Author Information
- Publication Type:Review
- Keywords: Benzo[a]pyrene; female reproduction; trophoblast; decidualization; miscarriage
- From: Journal of Environmental and Occupational Medicine 2024;41(12):1432-1437
- CountryChina
- Language:Chinese
- Abstract: Benzo[a]pyrene (BaP) is the most abundant environmental pollutant among polycyclic aromatic hydrocarbons (PAHs), and is widely distributed in air, water, soil, barbecue, and fried foods. Human beings are inevitably exposed to BaP. Studies have shown that BaP is reproductively toxic and is involved in diseases related to the female reproductive system by affecting the secretion of ovarian hormones, interfering with the function of ovarian mitochondria (affecting oocyte maturation), affecting embryo development (interfering with the migration of trophoblast cells, invasion, proliferation, apoptosis) and the process of metaplasia. This article summarized the research progress on the associations between BaP exposure and female reproductive function, miscarriage, and reproductive system tumors based on relevant studies at home and abroad in recent years, with a view to providing a basis and new direction for future research.
