Meta-analysis of the incidence and risk factors of anti-tuberculosis drug-induced liver injury
10.6039/j.issn.1001-0408.2024.24.15
- VernacularTitle:抗结核药物性肝损伤发生率及其危险因素的Meta分析
- Author:
Qinqin XIE
1
;
Huanhuan JI
;
Meiling GONG
;
Yuntao JIA
Author Information
1. 重庆医科大学药学院,重庆 400016;重庆医科大学附属儿童医院药学部/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿童感染与免疫罕见病重庆市重点实验室,重庆 400014
- Publication Type:Journal Article
- Keywords:
antitubercular agents;
drug-induced liver injury;
incidence;
risk factors;
meta-analysis
- From:
China Pharmacy
2024;35(24):3052-3058
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the incidence of anti-tuberculosis drug-induced liver injury(ATB-DILI)and its risk factors.METHODS PubMed,Embase,the Cochrane Library,Web of Science,China Knowledge Network,VIP,Wanfang data and China Biomedical Literature Database were searched to collect cohort studies and case-control studies on the incidence and risk factors of ATB-DILI from the establishment of the database to 31 May 2024.After screening literature,extracting data and evaluating the quality of literature,meta-analysis was performed using Stata 17.0 and RevMan 5.3 software.RESULTS A total of 26 literature involving 38 971 patients were included,of which 4 106 patients suffered from ATB-DILI.Meta-analysis showed that the incidence of ATB-DILI was 12.94％[95％CI(10.82％,15.06％),P＜0.001];subgroup analysis showed that the incidence of ATB-DILI in cohort studies,Chinese studies and pediatric patients was higher(P＜0.001).Age≥60 years,abnormal body mass index,alcoholism,smoking,history of liver disease,hepatitis B surface antigen positivity,extrapulmonary tuberculosis,malnutrition,hypoproteinemia,cardiovascular disease,diabetes mellitus,systemic lupus erythematosus,no prophylactic use of hepatoprotective drugs,and high baseline alanine transaminase levels were risk factors for developing ATB-DILI(P＜0.05).Sensitivity analysis and publication bias analysis showed that the results obtained in this study were relatively robust.CONCLUSIONS The incidence of ATB-DILI in tuberculosis patients is 12.94％.Age≥60 years,abnormal body mass index,alcoholism,smoking,history of liver disease,hepatitis B surface antigen positivity,extrapulmonary tuberculosis,malnutrition,hypoproteinaemia,cardiovascular disease,diabetes mellitus,systemic lupus erythematosus,non-prophy lactic use of hepatoprotective medications,and high baseline levels of alanine transaminase are the risk factors for developing ATB-DILI.
