Intestinal flora and risk of acute myeloid leukemia: a two-sample bidirectional mendelian randomization study
10.19405/j.cnki.issn1000-1492.2024.11.021
- Author:
Yanqun Zhou
1
;
Shibo Zhao
1
;
Liming Huang
1
Author Information
1. The Second Clinical Medical College of Guizhou University of Traditional Chinese Medicine , Guiyang 550000 ; Dept of Hematology , the Second Afiliated Hospital of Guizhou University of Traditional Chinese Medicine , Guiyang 550000
- Publication Type:Journal Article
- Keywords:
intestinal flora;
acute myeloid leukemia;
Mendelian randomisation;
causal relationship;
disease risk
- From:
Acta Universitatis Medicinalis Anhui
2024;59(11):2047-2051
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the causal relationship between the abundance of intestinal flora(IF) and the risk of developing acute myeloid leukemia(AML) using two-sample bidirectional Mendelian randomization(MR) methods.
Methods:The MiBioGen Consortium and FinnGen databases were utilized for the IF abundance and AML genome-wide association datasets, respectively. The primary analysis method entailed variance inverse weighting, supplemented by weighted median test, while heterogeneity was assessed using Cochran′sQtest. Additionally, MR-PRESSO was employed to identify any outliers, while MR-Egger intercept was utilized to evaluate horizontal pleotropy.
Results:Higher abundance of genetically determinedDialister(P=0.034,OR=4.373,95%CI:1.329-14.392),Veillonaceae(P=0.009,OR=2.029,95%CI:1.839-3.866), andLachnospiraceae UCG008(P=0.034,OR=3.827,95%CI:1.107-13.228) were found to be linked to an increased risk of AML. In contrast,Ruminococcaceae(P=0.042,OR=0.176, 95%CI:0.033-0.939) andPeptococcaceae(P=0.025,OR=0.168, 95%CI:0.035-0.803) were associated with a reduced risk of this disease.
Conclusion:Higher levels of theDialister, theVeillonellaceae, and theLachnospiraceae UCG008are risk factors for AML, while the familiesRuminococcaceaeandPeptococcaceaeare identified as protective factors against AML.
- Full text:202412261423582799肠道菌群与急性髓系白血病发...两样本双向孟德尔随机化研究_周艳群.pdf
