Research Progress of Nattokinase Delivery System

VernacularTitle:纳豆激酶递送系统研究进展
Author: Shuai LIU ¹ ; Xiaohui RONG ¹ ; Shufeng ZHANG ¹ ; Lei QU ¹ ; Fang LIU ² ; Juan JING ¹
Author Information

1. Department of Medical Technology Support, NCOs Academy of Army Medical University, Shijiazhuang 050081, China
2. Jingnan Medical District of PLA General Hospital, Beijing 100036, China
Publication Type:Journal Article
Keywords: protease ； nattokinase ； thrombolysis； dosage form
From: Chinese Journal of Modern Applied Pharmacy 2024;41(9):1295-1320
CountryChina
Language:Chinese
Abstract: Thromboembolic disease seriously affects people's health, and even endangers life. Nattokinase(NK) is an alkaline serine protease with strong thrombolytic activity and low toxicity. However, when NK passes through the stomach, it is degraded by gastric acid and pepsin, and subsequently loses its thrombolytic activity. The application of preparation technology can form a protective layer and improve the high bioavailability of NK. This article briefly introduced the pharmacological properties of NK, and discussed the characteristic of different dosage forms. The development of NK preparation was prospected in order to promote its research and application.