Effects of Different Proportions of Astragali Radix and Chuanxiong Rhizoma on the Extraction Kinetics of Flavonoids
10.13748/j.cnki.issn1007-7693.20231205
- VernacularTitle:黄芪、川芎不同比例配伍对黄酮类成分提取动力学的影响
- Author:
Yu ZHANG
1
;
Manyue ZHANG
2
;
Yun BI
2
;
Yali ZHAO
2
;
Jingmei SONG
2
;
Yuyan ZHANG
2
Author Information
1. Jinhua Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Jinhua 321000, China
2. Zhejiang Chinese Medical University, Hangzhou 310053, China
- Publication Type:Journal Article
- Keywords:
Astragali Radix；Chuanxiong Rhizoma ；compatibility；process of dynamics；mathematical model
- From:
Chinese Journal of Modern Applied Pharmacy
2024;41(9):1192-1197
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE :To study the effect of different proportion compatibility of Astragali Radix and Chuanxiong Rhizoma on the extraction kinetics of flavonoids.
METHODS
The content determination method of flavonoids(with rutin as the control substance) was established, and the concentrations of flavonoids in the extracts of Astragali Radix membranicum and Chuanxiong Rhizoma in different proportions(1∶1, 1∶2, 1∶3, 1∶4, 1∶5, 2∶1, 3∶1, 4∶1, 5∶1) were determined dynamically within 2 h, respectively. The extraction kinetics model was established according to Feck's first diffusion law. The extraction rate constant was calculated and the difference of dissolution kinetics was compared.
RESULTS
The compatibility of different proportions of Astragali Radix and Chuanxiong Rhizoma had significant effects on the extraction rate and concentration of flavonoids. The extraction kinetics models of flavonoids were consistent with the characteristics of the first-order kinetic equation. The extraction rate was the fastest when Astragali Radix ∶ Chuanxiong Rhizoma was 3∶1, the extraction rate was the slowest when Chuanxiong Rhizoma∶ Astragali Radix was 2∶1. The equilibrium concentration of flavonoids was the highest when Chuanxiong Rhizoma∶ Astragali Radix was 3∶1, when the ratio of Astragali Radix∶Chuanxiong Rhizoma was 5∶1, it was the lowest.
CONCLUSION
The compatibility of different proportions of Astragali Radix and Chuanxiong Rhizoma has a significant effect on the extraction rate and concentration of flavonoids.
