Modified MVAC as a Second-Line Treatment for Patients with Metastatic Urothelial Carcinoma after Failure of Gemcitabine and Cisplatin Treatment.
- Author:
Jung Hyun LEE
1
;
Sung Gu KANG
;
Seung Tae KIM
;
Seok Ho KANG
;
In Keun CHOI
;
Young Je PARK
;
Sang Chul OH
;
Deuk Jae SUNG
;
Jae Hong SEO
;
Jun CHEON
;
Sang Won SHIN
;
Yeul Hong KIM
;
Jun Suk KIM
;
Kyong Hwa PARK
Author Information
1. Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Urothelial carcinoma;
M-VAC protocol;
Second-line;
Cisplatin failure
- MeSH:
Anemia;
Cisplatin*;
Disease-Free Survival;
Doxorubicin;
Drug Therapy;
Follow-Up Studies;
Humans;
Methotrexate;
Neutropenia;
Retrospective Studies;
Vinblastine
- From:Cancer Research and Treatment
2014;46(2):172-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: There is no established standard second-line chemotherapy for patients with advanced or metastatic urothelial carcinoma (UC) who failed gemcitabine and cisplatin (GC) chemotherapy. This study was conducted in order to investigate the efficacy and toxicity of modified methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) in patients with metastatic UC previously treated with GC. MATERIALS AND METHODS: We retrospectively analyzed 28 patients who received modified MVAC between November 2004 and November 2012. All patients failed prior, first-line GC chemotherapy. RESULTS: The median age of patients was 64.0 years (range, 33.0 to 77.0 years), and 23 (82.1%) patients had an Eastern Cooperative Oncology Group performance status of 0 or 1. The overall response rate and the disease control rate were 36.0% and 64.0%, respectively. After a median follow-up period of 38 weeks (range, 5 to 182 weeks), median progression free survival was 21.0 weeks (95% confidence interval [CI], 6.3 to 35.7 weeks) and median overall survival was 49.0 weeks (95% CI, 18.8 to 79.3 weeks). Grade 3 or 4 hematological toxicities included neutropenia (n=21, 75.0%) and anemia (n=9, 32.1%). Grade 3 or 4 non-hematological toxicities did not occur and there was no treatment-related death. CONCLUSION: Modified MVAC appears to be a safe and active chemotherapy regimen in patients with stable physical status and adequate renal function after GC treatment.
