Investigation of blood lipid metabolism and risk factors of prognosis in children with systemic lupus erythematosus
10.3969/j.issn.1006-2483.2024.06.036
- VernacularTitle:强化降压治疗对老年高血压合并冠心病血脂相关指标的作用
- Author:
Qin CHENG
1
;
Xinyi WEI
1
;
Wei ZHANG
1
;
Sha LI
1
;
Jingwei LI
1
;
Yuanyuan PENG
1
;
Yu FANG
1
;
Xue XIE
1
Author Information
1. Department of Pediatric Rheumatology and Immunology , Chengdu Women's and Children's Central Hospital , School of Medicine , University of Electronic Science and Technology of China , Chengdu , Sichuan 611731 , China
- Publication Type:Journal Article
- Keywords:
Children;
Systemic lupus erythematosus;
Blood lipid metabolism
- From:
Journal of Public Health and Preventive Medicine
2024;35(6):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of blood lipid metabolism indicators and risk factors of prognosis in children with systemic lupus erythematosus (SLE). Methods A total of 54 children who were diagnosed with SLE and hospitalized in Chengdu Women and Children’ s Central Hospital from January 2013 to August 2022 were selected. Clinical data of all children were collected and blood lipid metabolism indicators and biochemical indicators were detected , and binary logistic regression was used to analyze the prognosis risk factors in children with SLE. Results Among the 47 cases (87.04%) had abnormal blood lipid metabolism at admission, and is mainly manifested as elevated levels of LDL-C, TG and TC and decreased level of HDL-C. The proportion of cardiovascular system damage, hematological system damage, urinary protein positivity, and SLEDAI-2000 score in the group with good prognosis were lower than those in the group with poor prognosis, while the proportion of dsDNA positivity was higher in the group with poor prognosis. Binary Logistic regression analysis showed that the cardiovascular system damage and positive urinary protein were risk factors for poor prognosis, with statistically significant differences (P<0.05). Conclusion Abnormal blood lipid metabolism is common in children with SLE, and cardiovascular system damage and positive urinary protein may increase the risk of poor prognosis in young children.
