A Case of Idiopathic T-cell Mediated Chronic Conjunctivitis With Limbitis Treated Using Oral Cyclosporine.
10.3341/jkos.2007.48.11.1567
- Author:
Jung Hyun PARK
1
;
Won Ryang WEE
;
Jin Hak LEE
;
Mee Kum KIM
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. kmk9@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Conjunctivitis;
Limbitis;
Cyclosporine;
T cell
- MeSH:
Adult;
Anti-Bacterial Agents;
B-Lymphocytes;
Basement Membrane;
Conjunctiva;
Conjunctivitis*;
Connective Tissue Diseases;
Cornea;
Cyclosporine*;
Diagnosis, Oral;
Humans;
Inflammation;
Intraocular Pressure;
Ophthalmic Solutions;
Pemphigoid, Bullous;
Steroids;
Stevens-Johnson Syndrome;
T-Lymphocytes*
- From:Journal of the Korean Ophthalmological Society
2007;48(11):1567-1572
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of refractory idiopathic T cell mediated chronic conjunctivitis causing limbal insufficiency, which improved with cyclosporine therapy. CASE SUMMARY: A 43-year old man complained of conjunctival injection and discomfort in both eyes that lasted three years and was refractory to topical steroids, antibiotics, and artificial tears. There was no evidence of connective tissue diseases, Stevens-Johnson syndrome, pemphigoid, or drug history. Both eyes presented with diffuse injection and thickening of the conjunctiva, punctuated epithelial erosion of the conjunctiva and cornea, severe limbal epithelitis and elevated intraocular pressure. The left cornea was conjunctivalized due to limbal deficiency. Histological examination revealed severe infiltration of T and B cells, without any evidence of tumor cells or basement membrane anomaly. When treated with oral cyclosporine, injection and thickening of the conjunctiva decreased and the intraocular pressure was normalized. The surface inflammation of both eyes completely resolved two months after the treatment was initiated. CONCLUSIONS: In chronic idiopathic conjunctivitis with limbitis resistant to conventional treatment and T cell infiltration found in pathological examination, oral cyclosporine therapy might be required to resolve inflammation.
