Research progress on inhalation nano-drug delivery systems of active ingredients of traditional Chinese medicine for pulmonary diseases
10.6039/j.issn.1001-0408.2024.23.19
- VernacularTitle:治疗肺部疾病的中药活性成分可吸入纳米给药系统研究进展
- Author:
Fangrui CHENG
1
;
Shuang SUN
1
;
Huan ZHANG
1
;
Yongji LI
1
;
Shaowa LYU
1
Author Information
1. 黑龙江中医药大学药学院/教育部北药基础与应用研究重点实验室,哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
inhalation nano-drug delivery systems;
active ingredients of traditional Chinese medicine;
pulmonary diseases
- From:
China Pharmacy
2024;35(23):2954-2958
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary administration can directly deliver drugs to the lungs,making it the preferred mode of administration for pulmonary disease. Active ingredients of traditional Chinese medicine (TCM),such as quercetin and paclitaxel have demonstrated promising therapeutic effects on lung diseases. However,they face challenges such as poor water solubility and high lung clearance rates. Loading the active ingredients of TCM onto nano-drug delivery systems can enhance their water solubility,stability,permeability and retention in the lungs. Based on this,this study reviewed the research progress on inhalation nano-drug delivery systems for the active ingredients of TCM in the treatment of lung diseases. It was found that there are nano-drug delivery systems for TCM active ingredients based on chitosan,lipids (including liposomes,solid lipid nanoparticles,and nanostructured lipid carriers),and targeting ligands (including targeting folate receptor,targeting transferrin receptor,and exosomes). These inhalation nano-drug delivery systems comprehensively consider key factors such as particle size,surface charge,and hydrophobicity,which can prevent the drugs from being cleared by mucus,cilium and macrophages,thus exhibiting great potential for application.
