Screening and content determination of differential quality markers in Zingiber officinale mixed and triturated with Schisandra chinensis before and after processing
10.6039/j.issn.1001-0408.2024.23.06
- VernacularTitle:干姜拌捣五味子临方炮制前后差异质量标志物筛选及其含量测定
- Author:
Pei ZHONG
1
;
Jianglin XUE
;
Quan ZHAO
;
Chanming LIU
;
Xiaojing YAN
;
Dan SU
;
Yonggui SONG
;
Tulin LU
;
Wei HUANG
Author Information
1. 南京中医药大学常州附属医院药学部,江苏常州 213003
- Publication Type:Journal Article
- Keywords:
Zingiber officinale;
Schisandra chinensis;
differential Q-Marker;
HPLC;
fingerprint
- From:
China Pharmacy
2024;35(23):2870-2876
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To screen and quantitatively analyze differential quality markers (Q-Marker) in Zingiber officinale mixed and triturated with Schisandra chinensis (ZMTS) before and after processing. METHODS HPLC fingerprints of before processing[Z. officinale complicated with S. chinensis (ZWS)]and after processing (ZMTS) (10 batches each) were established. The differences of Q-Markers before and after processing were screened by the chemical pattern recognition method and Q-Marker "five principles",and the contents were determined. RESULTS A total of 14 common peaks were identified in the fingerprints of ZWS,22 common peaks were identified in the fingerprints of ZMTS,and 8 components were identified. Differential Q-Marker were screened by chemical pattern recognition and Q-Marker "five principles",i. e. 6-gingerol,schisandrol A,schisandrol B,8-gingerol,10-gingerol,schisandrin A,schisandrin B,schizandrin C. The average contents of the 8 differential Q-Markers in ZMTS were 229.46,244.48,39.96,44.12,61.17,47.82,100.11 and 9.70 μg/g,respectively. The average contents of the 4 differential Q-Markers (6-gingerol,schisandrol A,schisandrol B,8-gingerol) in ZWS were 112.58,19.01,26.74 and 5.98 μg/g,respectively. CONCLUSIONS In this study,the differential Q-Markers before and after ZMTS processing are screened. The contents of the Q-Markers in ZMTS after processing are higher than those before processing.
